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Showing Protein Syntaxin-1A (HMDBP14643)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14643
Secondary Accession Numbers None
Name Syntaxin-1A
Synonyms
  1. Neuron-specific antigen HPC-1
Gene Name STX1A
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:17502420, PubMed:28596237, PubMed:28031464). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:12101244). Plays also an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (PubMed:17502420, PubMed:28596237, PubMed:28031464).
Pathways
  • Amphetamine addiction
  • Huntington disease
  • Insulin secretion
  • Pathways of neurodegeneration - multiple diseases
  • SNARE interactions in vesicular transport
  • Synaptic vesicle cycle
Reactions Not Available
GO Classification
Biological Process
protein localization to membrane
intracellular protein transport
positive regulation of neurotransmitter secretion
positive regulation of exocytosis
synaptic vesicle fusion to presynaptic active zone membrane
synaptic vesicle endocytosis
vesicle docking
positive regulation of excitatory postsynaptic membrane potential
calcium ion-dependent exocytosis
vesicle fusion
regulation of exocytosis
exocytosis
response to gravity
positive regulation of calcium ion-dependent exocytosis
protein sumoylation
positive regulation of catecholamine secretion
synaptic vesicle exocytosis
synaptic vesicle docking
SNARE complex assembly
secretion by cell
regulation of synaptic vesicle priming
regulated exocytosis
positive regulation of norepinephrine secretion
insulin secretion
modulation of excitatory postsynaptic potential
hormone secretion
Cellular Component
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
integral component of presynaptic membrane
synaptobrevin 2-SNAP-25-syntaxin-1a complex
SNARE complex
presynaptic active zone membrane
intracellular organelle
voltage-gated potassium channel complex
integral component of synaptic vesicle membrane
synaptic vesicle membrane
plasma membrane
endomembrane system
membrane
axon
integral to plasma membrane
presynaptic membrane
secretory granule
neuron projection
nuclear membrane
synaptic vesicle
postsynaptic density
acrosomal vesicle
actomyosin
integral to membrane
glutamatergic synapse
protein-containing complex
Molecular Function
protein domain specific binding
protein N-terminus binding
identical protein binding
protein-containing complex binding
SNAP receptor activity
calcium-dependent protein binding
SNARE binding
myosin head/neck binding
myosin binding
kinase binding
chloride channel inhibitor activity
calcium channel inhibitor activity
ion channel binding
ATP-dependent protein binding
protein-macromolecule adaptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 288
Molecular Weight 33054.145
Theoretical pI 5.236
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 266-286;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID O35526
UniProtKB/Swiss-Prot Entry Name STX1A_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  2. Torii S, Zhao S, Yi Z, Takeuchi T, Izumi T: Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a. Mol Cell Biol. 2002 Aug;22(15):5518-26. doi: 10.1128/MCB.22.15.5518-5526.2002. [PubMed:12101244 ]
  3. Hutt DM, Baltz JM, Ngsee JK: Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction. J Biol Chem. 2005 May 27;280(21):20197-203. doi: 10.1074/jbc.M412920200. Epub 2005 Mar 17. [PubMed:15774481 ]
  4. Roux I, Safieddine S, Nouvian R, Grati M, Simmler MC, Bahloul A, Perfettini I, Le Gall M, Rostaing P, Hamard G, Triller A, Avan P, Moser T, Petit C: Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell. 2006 Oct 20;127(2):277-89. doi: 10.1016/j.cell.2006.08.040. [PubMed:17055430 ]
  5. Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL: Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22. doi: 10.1074/mcp.T500041-MCP200. Epub 2006 Feb 1. [PubMed:16452087 ]
  6. Park WJ, Lee SE, Kwon NS, Baek KJ, Kim DS, Yun HY: Leucine-rich glioma inactivated 3 associates with syntaxin 1. Neurosci Lett. 2008 Oct 31;444(3):240-4. doi: 10.1016/j.neulet.2008.08.044. Epub 2008 Aug 20. [PubMed:18760330 ]
  7. Ito H, Atsuzawa K, Morishita R, Usuda N, Sudo K, Iwamoto I, Mizutani K, Katoh-Semba R, Nozawa Y, Asano T, Nagata K: Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin. J Neurochem. 2009 Feb;108(4):867-80. doi: 10.1111/j.1471-4159.2008.05849.x. [PubMed:19196426 ]
  8. Bhatnagar S, Oler AT, Rabaglia ME, Stapleton DS, Schueler KL, Truchan NA, Worzella SL, Stoehr JP, Clee SM, Yandell BS, Keller MP, Thurmond DC, Attie AD: Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion. PLoS Genet. 2011 Oct;7(10):e1002323. doi: 10.1371/journal.pgen.1002323. Epub 2011 Oct 6. [PubMed:21998599 ]
  9. Zhang Z, Takeuchi H, Gao J, Wang D, James DJ, Martin TFJ, Hirata M: PRIP (phospholipase C-related but catalytically inactive protein) inhibits exocytosis by direct interactions with syntaxin 1 and SNAP-25 through its C2 domain. J Biol Chem. 2013 Mar 15;288(11):7769-7780. doi: 10.1074/jbc.M112.419317. Epub 2013 Jan 22. [PubMed:23341457 ]
  10. Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL: The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1. Diabetes. 2017 Sep;66(9):2327-2338. doi: 10.2337/db16-1403. Epub 2017 Jun 8. [PubMed:28596237 ]
  11. Liang T, Qin T, Xie L, Dolai S, Zhu D, Prentice KJ, Wheeler M, Kang Y, Osborne L, Gaisano HY: New Roles of Syntaxin-1A in Insulin Granule Exocytosis and Replenishment. J Biol Chem. 2017 Feb 10;292(6):2203-2216. doi: 10.1074/jbc.M116.769885. Epub 2016 Dec 28. [PubMed:28031464 ]
  12. Tan GH, Liu YY, Wang L, Li K, Zhang ZQ, Li HF, Yang ZF, Li Y, Li D, Wu MY, Yu CL, Long JJ, Chen RC, Li LX, Yin LP, Liu JW, Cheng XW, Shen Q, Shu YS, Sakimura K, Liao LJ, Wu ZY, Xiong ZQ: PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. Cell Res. 2018 Jan;28(1):90-110. doi: 10.1038/cr.2017.128. Epub 2017 Oct 20. [PubMed:29056747 ]