| Identification |
|---|
| HMDB Protein ID
| HMDBP14628 |
| Secondary Accession Numbers
| None |
| Name
| Mu-conotoxin TsIIIA |
| Synonyms
|
Not Available
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin specifically inhibits mammalian Nav1.8/SCN10A sodium currents (IC(50)=2.11 uM) without inducing a shift in the current-voltage relationship of this channel (PubMed:32758497). In vivo, shows potent analgesic activity in a mice hotplate analgesic assay (PubMed:28219625). In addition, this toxin has better analgesic effects than Ziconotide, an analgesic drug (PubMed:28219625). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| pathogenesis |
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| ion channel inhibitor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 7462.71 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| H2BKS9 |
| UniProtKB/Swiss-Prot Entry Name
| CM3A_CONTS |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Zhou M, Wang L, Wu Y, Zhu X, Feng Y, Chen Z, Li Y, Sun D, Ren Z, Xu A: Characterizing the evolution and functions of the M-superfamily conotoxins. Toxicon. 2013 Dec 15;76:150-9. doi: 10.1016/j.toxicon.2013.09.020. Epub 2013 Sep 27. [PubMed:24080356 ]
- Yang M, Zhao S, Min X, Shao M, Chen Y, Chen Z, Zhou M: A novel mu-conotoxin from worm-hunting Conus tessulatus that selectively inhibit rat TTX-resistant sodium currents. Toxicon. 2017 May;130:11-18. doi: 10.1016/j.toxicon.2017.02.013. Epub 2017 Feb 17. [PubMed:28219625 ]
- Yang M, Zhou M: mu-conotoxin TsIIIA, a peptide inhibitor of human voltage-gated sodium channel hNav1.8. Toxicon. 2020 Oct 30;186:29-34. doi: 10.1016/j.toxicon.2020.07.024. Epub 2020 Aug 3. [PubMed:32758497 ]
|
