| Identification |
|---|
| HMDB Protein ID
| HMDBP14623 |
| Secondary Accession Numbers
| None |
| Name
| Plasmanylethanolamine desaturase |
| Synonyms
|
- Carotenogenesis protein CarF
- CarF
|
| Gene Name
| CARF |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the membrane, required for light-induced carotenogenesis (PubMed:12519205, PubMed:18310035, PubMed:22267513, PubMed:31604315). Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms, most precisely in sensing photooxidative stress through singlet oxygen (PubMed:31604315). Participates in the light-dependent inactivation of the antisigma factor CarR (PubMed:12519205, PubMed:18310035). Mediates signaling by singlet oxygen, generated via photoexcited protoporphyrin IX (PubMed:22267513). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| ether lipid biosynthetic process |
| Cellular Component |
| integral to membrane |
| plasma membrane |
| Molecular Function |
| plasmanylethanolamine desaturase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 31210.15 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 29-45;59-75;124-138;143-159;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9AE87 |
| UniProtKB/Swiss-Prot Entry Name
| CARF_MYXXA |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Gallego-Garcia A, Monera-Girona AJ, Pajares-Martinez E, Bastida-Martinez E, Perez-Castano R, Iniesta AA, Fontes M, Padmanabhan S, Elias-Arnanz M: A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis. Science. 2019 Oct 4;366(6461):128-132. doi: 10.1126/science.aay1436. [PubMed:31604315 ]
- Fontes M, Galbis-Martinez L, Murillo FJ: A novel regulatory gene for light-induced carotenoid synthesis in the bacterium Myxococcus xanthus. Mol Microbiol. 2003 Jan;47(2):561-71. doi: 10.1046/j.1365-2958.2003.03319.x. [PubMed:12519205 ]
- Galbis-Martinez L, Galbis-Martinez M, Murillo FJ, Fontes M: An anti-antisigma factor in the response of the bacterium Myxococcus xanthus to blue light. Microbiology (Reading). 2008 Mar;154(Pt 3):895-904. doi: 10.1099/mic.0.2007/013359-0. [PubMed:18310035 ]
- Galbis-Martinez M, Padmanabhan S, Murillo FJ, Elias-Arnanz M: CarF mediates signaling by singlet oxygen, generated via photoexcited protoporphyrin IX, in Myxococcus xanthus light-induced carotenogenesis. J Bacteriol. 2012 Mar;194(6):1427-36. doi: 10.1128/JB.06662-11. Epub 2012 Jan 20. [PubMed:22267513 ]
|
