| Identification |
|---|
| HMDB Protein ID
| HMDBP14613 |
| Secondary Accession Numbers
| None |
| Name
| Exendin-2-long |
| Synonyms
|
Not Available
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Has vasoactive intestinal peptide(VIP)/secretin-like biological activity. Interacts with rat and human VIP receptors 1 (VIPR1) and 2 (VIPR2), with the highest affinity for the human VIPR2. Induces hypotension that is mediated by relaxation of cardiac smooth muscle. This vasodilation may not be transduced by VIP or PACAP receptors. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| regulation of blood pressure |
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| hormone activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 9530.965 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P04204 |
| UniProtKB/Swiss-Prot Entry Name
| EXE2_HELSU |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Fry BG, Roelants K, Winter K, Hodgson WC, Griesman L, Kwok HF, Scanlon D, Karas J, Shaw C, Wong L, Norman JA: Novel venom proteins produced by differential domain-expression strategies in beaded lizards and gila monsters (genus Heloderma). Mol Biol Evol. 2010 Feb;27(2):395-407. doi: 10.1093/molbev/msp251. Epub 2009 Oct 15. [PubMed:19837656 ]
- Pohl M, Wank SA: Molecular cloning of the helodermin and exendin-4 cDNAs in the lizard. Relationship to vasoactive intestinal polypeptide/pituitary adenylate cyclase activating polypeptide and glucagon-like peptide 1 and evidence against the existence of mammalian homologues. J Biol Chem. 1998 Apr 17;273(16):9778-84. doi: 10.1074/jbc.273.16.9778. [PubMed:9545315 ]
- Vandermeers-Piret MC, Vandermeers A, Gourlet P, Ali MH, Waelbroeck M, Robberecht P: Evidence that the lizard helospectin peptides are O-glycosylated. Eur J Biochem. 2000 Jul;267(14):4556-60. doi: 10.1046/j.1432-1327.2000.01506.x. [PubMed:10880980 ]
- Gourlet P, Vandermeers A, Van Rampelbergh J, De Neef P, Cnudde J, Waelbroeck M, Robberecht P: Analogues of VIP, helodermin, and PACAP discriminate between rat and human VIP1 and VIP2 receptors. Ann N Y Acad Sci. 1998 Dec 11;865:247-52. doi: 10.1111/j.1749-6632.1998.tb11184.x. [PubMed:9928018 ]
- Tsueshita T, Onyukusel H, Sethi V, Gandhi S, Rubinstein I: Helospectin I and II evoke vasodilation in the intact peripheral microcirculation. Peptides. 2004 Jan;25(1):65-9. doi: 10.1016/j.peptides.2003.11.010. [PubMed:15003357 ]
- Hoshino M, Yanaihara C, Hong YM, Kishida S, Katsumaru Y, Vandermeers A, Vandermeers-Piret MC, Robberecht P, Christophe J, Yanaihara N: Primary structure of helodermin, a VIP-secretin-like peptide isolated from Gila monster venom. FEBS Lett. 1984 Dec 10;178(2):233-9. doi: 10.1016/0014-5793(84)80607-9. [PubMed:6439576 ]
- Vandermeers A, Gourlet P, Vandermeers-Piret MC, Cauvin A, De Neef P, Rathe J, Svoboda M, Robberecht P, Christophe J: Chemical, immunological and biological properties of peptides like vasoactive-intestinal-peptide and peptide-histidine-isoleucinamide extracted from the venom of two lizards (Heloderma horridum and Heloderma suspectum). Eur J Biochem. 1987 Apr 15;164(2):321-7. doi: 10.1111/j.1432-1033.1987.tb11061.x. [PubMed:3569266 ]
- Blankenfeldt W, Nokihara K, Naruse S, Lessel U, Schomburg D, Wray V: NMR spectroscopic evidence that helodermin, unlike other members of the secretin/VIP family of peptides, is substantially structured in water. Biochemistry. 1996 May 14;35(19):5955-62. doi: 10.1021/bi9601520. [PubMed:8634236 ]
|
