| Identification |
|---|
| HMDB Protein ID
| HMDBP14596 |
| Secondary Accession Numbers
| None |
| Name
| Acidic phospholipase A2 Omo-E6 |
| Synonyms
|
- svPLA2
- Phosphatidylcholine 2-acylhydrolase
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Snake venom phospholipase A2 (PLA2) that inhibits the ADP- and collagen-induced human platelet aggregation (By similarity). Exhibits strong hydrolytic activities and prefers the anionic micelles (dPPC with deoxycholate) to the zwitterionic micelles (dPPC with Triton X-100). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| phospholipid metabolic process |
| lipid catabolic process |
| arachidonic acid secretion |
| Cellular Component |
| extracellular region |
| host extracellular space |
| Molecular Function |
| calcium ion binding |
| phospholipase A2 activity |
| toxin activity |
| phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) |
| phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 3262.8 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0DJJ7 |
| UniProtKB/Swiss-Prot Entry Name
| PA2A_OVOMO |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Tsai IH, Tsai TS, Wang YM, Tu MC, Chang HC: Cloning and characterization of Trimeresurus gracilis venom phospholipases A(2): comparison with Ovophis okinavensis venom and the systematic implications. Toxicon. 2012 Jan;59(1):151-7. doi: 10.1016/j.toxicon.2011.10.016. Epub 2011 Nov 17. [PubMed:22115990 ]
|
