| Identification |
|---|
| HMDB Protein ID
| HMDBP14570 |
| Secondary Accession Numbers
| None |
| Name
| Pneumolysin |
| Synonyms
|
- PLY
- Thiol-activated cytolysin
|
| Gene Name
| PLY |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes (Probable). After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| pathogenesis |
| hemolysis in other organism |
| Cellular Component |
| integral to membrane |
| extracellular region |
| cell wall |
| host cell plasma membrane |
| Molecular Function |
| cholesterol binding |
| toxin activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 471 |
| Molecular Weight
| 52898.05 |
| Theoretical pI
| 5.352 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- 158-171;178-187;256-265;273-285;
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0C2J9 |
| UniProtKB/Swiss-Prot Entry Name
| TACY_STRPN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM: Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science. 2001 Jul 20;293(5529):498-506. doi: 10.1126/science.1061217. [PubMed:11463916 ]
- Bandara M, Skehel JM, Kadioglu A, Collinson I, Nobbs AH, Blocker AJ, Jenkinson HF: The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation. Microbes Infect. 2017 Jul - Aug;19(7-8):402-412. doi: 10.1016/j.micinf.2017.04.003. Epub 2017 Apr 27. [PubMed:28456649 ]
|
