| Identification |
|---|
| HMDB Protein ID
| HMDBP14544 |
| Secondary Accession Numbers
| None |
| Name
| Forkhead box protein H1 |
| Synonyms
|
- Forkhead activin signal transducer 1
- Forkhead activin signal transducer 2
- Fast-1
- hFAST-1
- Fast-2
|
| Gene Name
| FOXH1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| heart looping |
| embryonic heart tube anterior/posterior pattern specification |
| axial mesoderm development |
| secondary heart field specification |
| nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry |
| cardiac right ventricle morphogenesis |
| ventricular trabecula myocardium morphogenesis |
| negative regulation of androgen receptor signaling pathway |
| cellular response to cytokine stimulus |
| outflow tract morphogenesis |
| aorta morphogenesis |
| negative regulation of sequence-specific DNA binding transcription factor activity |
| negative regulation of intracellular estrogen receptor signaling pathway |
| positive regulation of transcription from RNA polymerase II promoter |
| positive regulation of transcription, DNA-dependent |
| negative regulation of transcription from RNA polymerase II promoter |
| transforming growth factor beta receptor signaling pathway |
| Cellular Component |
| nucleoplasm |
| nucleus |
| chromatin |
| transcription factor complex |
| activin responsive factor complex |
| Molecular Function |
| co-SMAD binding |
| core promoter proximal region sequence-specific DNA binding |
| bHLH transcription factor binding |
| SMAD binding |
| R-SMAD binding |
| protein domain specific binding |
| transcription regulatory region sequence-specific DNA binding |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| sequence-specific DNA binding |
| sequence-specific DNA binding transcription factor activity |
| androgen receptor binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 365 |
| Molecular Weight
| 39256.61 |
| Theoretical pI
| 9.514 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O75593 |
| UniProtKB/Swiss-Prot Entry Name
| FOXH1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B: Characterization of human FAST-1, a TGF beta and activin signal transducer. Mol Cell. 1998 Jul;2(1):121-7. [PubMed:9702198 ]
|
