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Showing Protein Denticleless protein homolog (HMDBP14540)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14540
Secondary Accession Numbers None
Name Denticleless protein homolog
Synonyms Not Available
Gene Name DTL
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity). May play a role in the regulation of the circadian clock (By similarity).
Pathways
  • protein ubiquitination
Reactions Not Available
GO Classification
Biological Process
regulation of cell cycle
mitotic G2 DNA damage checkpoint
signal transduction involved in G2 DNA damage checkpoint
rhythmic process
protein monoubiquitination
ubiquitin-dependent protein catabolic process
protein polyubiquitination
translesion synthesis
response to UV
response to DNA damage stimulus
DNA replication
Cellular Component
cytoplasm
centrosome
chromosome
Cul4A-RING E3 ubiquitin ligase complex
Cul4B-RING E3 ubiquitin ligase complex
nucleus
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 647
Molecular Weight 70768.13
Theoretical pI 9.37
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q5RHI5
UniProtKB/Swiss-Prot Entry Name DTL_DANRE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA: DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Genes Dev. 2006 Nov 15;20(22):3117-29. doi: 10.1101/gad.1482106. Epub 2006 Nov 3. [PubMed:17085480 ]