Hmdb loader
Identification
HMDB Protein ID HMDBP14534
Secondary Accession Numbers None
Name Dachshund homolog 1
Synonyms
  1. Dach1
Gene Name DACH1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1 (By similarity). Binds to chromatin DNA via its DACHbox-N domain.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
regulation of transcription from RNA polymerase II promoter
suckling behavior
regulation of nuclear cell cycle DNA replication
development of primary female sexual characteristics
negative regulation of DNA biosynthetic process
negative regulation of transcription by competitive promoter binding
negative regulation of cell proliferation involved in contact inhibition
respiratory gaseous exchange
negative regulation of fibroblast proliferation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-dependent
cell proliferation
regulation of transcription, DNA-dependent
negative regulation of cell migration
Cellular Component
transcription factor complex
cytoplasm
nucleus
Molecular Function
sequence-specific DNA binding transcription factor activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II transcription regulatory region sequence-specific DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 751
Molecular Weight 77970.78
Theoretical pI 8.522
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9QYB2
UniProtKB/Swiss-Prot Entry Name DACH1_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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