| Identification |
|---|
| HMDB Protein ID
| HMDBP14529 |
| Secondary Accession Numbers
| None |
| Name
| Endoglin |
| Synonyms
|
Not Available
|
| Gene Name
| ENG |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to integrins (By similarity). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8294451). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| cell adhesion |
| angiogenesis |
| transforming growth factor beta receptor signaling pathway |
| cell migration |
| epithelial to mesenchymal transition |
| vasculogenesis |
| regulation of transforming growth factor beta receptor signaling pathway |
| Cellular Component |
| integral to membrane |
| plasma membrane |
| extracellular space |
| cell surface |
| Molecular Function |
| glycosaminoglycan binding |
| type I transforming growth factor beta receptor binding |
| type II transforming growth factor beta receptor binding |
| transforming growth factor beta-activated receptor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 653 |
| Molecular Weight
| 70278.99 |
| Theoretical pI
| 5.852 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P37176 |
| UniProtKB/Swiss-Prot Entry Name
| EGLN_PIG |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Yamashita H, Ichijo H, Grimsby S, Moren A, ten Dijke P, Miyazono K: Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta. J Biol Chem. 1994 Jan 21;269(3):1995-2001. [PubMed:8294451 ]
|
