| Identification |
|---|
| HMDB Protein ID
| HMDBP14523 |
| Secondary Accession Numbers
| None |
| Name
| Chordin |
| Synonyms
|
Not Available
|
| Gene Name
| CHRD |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. |
| Pathways
|
- TGF-beta signaling pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| dorsal/ventral pattern formation |
| BMP signaling pathway involved in spinal cord dorsal/ventral patterning |
| positive regulation of mesenchymal cell proliferation |
| negative regulation of BMP signaling pathway |
| negative regulation of osteoblast differentiation |
| gastrulation with mouth forming second |
| positive regulation of cell adhesion |
| mesoderm formation |
| negative regulation of cell migration |
| osteoblast differentiation |
| skeletal system development |
| forebrain development |
| pattern specification process |
| central nervous system development |
| Cellular Component |
| extracellular space |
| Molecular Function |
| syndecan binding |
| heparin binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 948 |
| Molecular Weight
| 101512.395 |
| Theoretical pI
| 7.5 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9Z0E2 |
| UniProtKB/Swiss-Prot Entry Name
| CHRD_MOUSE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Pappano WN, Scott IC, Clark TG, Eddy RL, Shows TB, Greenspan DS: Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes. Genomics. 1998 Sep 1;52(2):236-9. doi: 10.1006/geno.1998.5474. [PubMed:9782094 ]
- Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS: Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling. Nature. 2001 Mar 22;410(6827):475-8. doi: 10.1038/35068572. [PubMed:11260715 ]
|
