| Identification |
|---|
| HMDB Protein ID
| HMDBP14502 |
| Secondary Accession Numbers
| None |
| Name
| SKI family transcriptional corepressor 2 |
| Synonyms
|
- Functional Smad-suppressing element on chromosome 18
- LBX1 corepressor 1-like protein
- Ladybird homeobox corepressor 1-like protein
- Fussel-18
|
| Gene Name
| SKOR2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| regulation of transcription, DNA-dependent |
| negative regulation of transcription from RNA polymerase II promoter |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| negative regulation of BMP signaling pathway |
| Cellular Component |
| cytoplasm |
| nucleus |
| transcription factor complex |
| Molecular Function |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| sequence-specific double-stranded DNA binding |
| SMAD binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 1001 |
| Molecular Weight
| 104234.19 |
| Theoretical pI
| 6.487 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q2VWA4 |
| UniProtKB/Swiss-Prot Entry Name
| SKOR2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES: DNA sequence and analysis of human chromosome 18. Nature. 2005 Sep 22;437(7058):551-5. [PubMed:16177791 ]
- Arndt S, Poser I, Schubert T, Moser M, Bosserhoff AK: Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues. Lab Invest. 2005 Nov;85(11):1330-41. [PubMed:16200078 ]
|
