| Identification |
|---|
| HMDB Protein ID
| HMDBP14466 |
| Secondary Accession Numbers
| None |
| Name
| Transforming growth factor beta-3 proprotein |
| Synonyms
|
Not Available
|
| Gene Name
| TGFB3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity).Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). |
| Pathways
|
- Cell cycle
- Cellular senescence
- Cytokine-cytokine receptor interaction
- FoxO signaling pathway
- MAPK signaling pathway
- TGF-beta signaling pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| positive regulation of bone mineralization |
| negative regulation of macrophage cytokine production |
| mesenchyme migration |
| detection of hypoxia |
| cardiac epithelial to mesenchymal transition |
| epithelial to mesenchymal transition involved in endocardial cushion formation |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| ossification involved in bone remodeling |
| salivary gland morphogenesis |
| SMAD protein signal transduction |
| positive regulation of epithelial to mesenchymal transition |
| cell-cell junction organization |
| cell activation |
| spleen development |
| BMP signaling pathway |
| positive regulation of collagen biosynthetic process |
| positive regulation of cell migration |
| regulation of cell proliferation |
| transforming growth factor beta receptor signaling pathway |
| positive regulation of cell proliferation |
| response to progesterone stimulus |
| positive regulation of cell division |
| face morphogenesis |
| positive regulation of transcription, DNA-dependent |
| nervous system development |
| negative regulation of cell proliferation |
| response to hypoxia |
| embryonic digestive tract development |
| Cellular Component |
| extracellular space |
| extracellular matrix |
| Molecular Function |
| identical protein binding |
| type III transforming growth factor beta receptor binding |
| type II transforming growth factor beta receptor binding |
| type I transforming growth factor beta receptor binding |
| growth factor activity |
| cytokine activity |
| transforming growth factor beta binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 412 |
| Molecular Weight
| 47077.395 |
| Theoretical pI
| 6.992 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P16047 |
| UniProtKB/Swiss-Prot Entry Name
| TGFB3_CHICK |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Jakowlew SB, Dillard PJ, Kondaiah P, Sporn MB, Roberts AB: Complementary deoxyribonucleic acid cloning of a novel transforming growth factor-beta messenger ribonucleic acid from chick embryo chondrocytes. Mol Endocrinol. 1988 Aug;2(8):747-55. doi: 10.1210/mend-2-8-747. [PubMed:3211158 ]
- Burt DW, Dey BR, Paton IR, Morrice DR, Law AS: The chicken transforming growth factor-beta 3 gene: genomic structure, transcriptional analysis, and chromosomal location. DNA Cell Biol. 1995 Feb;14(2):111-23. doi: 10.1089/dna.1995.14.111. [PubMed:7865129 ]
- Burt DW, Paton IR, Dey BR: Comparative analysis of human and chicken transforming growth factor-beta 2 and -beta 3 promoters. J Mol Endocrinol. 1991 Dec;7(3):175-83. doi: 10.1677/jme.0.0070175. [PubMed:1840616 ]
- Jakowlew SB, Lechleider R, Geiser AG, Kim SJ, Santa-Coloma TA, Cubert J, Sporn MB, Roberts AB: Identification and characterization of the chicken transforming growth factor-beta 3 promoter. Mol Endocrinol. 1992 Aug;6(8):1285-98. doi: 10.1210/mend.6.8.1406706. [PubMed:1406706 ]
|
