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Showing Protein Caspase-4 (HMDBP14455)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14455
Secondary Accession Numbers None
Name Caspase-4
Synonyms
  1. CASP-4
  2. Caspase-11
  3. Protease ICH-3
  4. CASP-11
Gene Name CASP4
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Inflammatory caspase that acts as an essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS, as well as infection with Gram-negative bacteria (PubMed:8702803, PubMed:9038361, PubMed:22002608, PubMed:25119034). Thiol protease that cleaves a tetrapeptide after an Asp residue at position P1 (By similarity). Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, followed by IL1A, IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed:22002608, PubMed:26320999, PubMed:26375003). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection: in later stages of the infection, LPS from cytosolic Salmonella triggers CASP4 activation, which catalyzes cleavage of GSDMD, resulting in pyroptosis of infected cells and their extrusion into the gut lumen, as well as in IL18 secretion (PubMed:25121752, PubMed:26375003). Cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32554464, PubMed:32109412). Pyroptosis limits bacterial replication, while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation (PubMed:25121752). Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (By similarity). Involved in cell death induced by endoplasmic reticulum stress (By similarity). Activated by direct binding to LPS without the need of an upstream sensor (PubMed:25119034). Does not directly process IL1B (PubMed:8702803, PubMed:9038361). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).
Pathways
  • Neutrophil extracellular trap formation
  • NOD-like receptor signaling pathway
  • Salmonella infection
Reactions Not Available
GO Classification
Biological Process
intrinsic apoptotic signaling pathway
positive regulation of tumor necrosis factor-mediated signaling pathway
pyroptosis
execution phase of apoptosis
positive regulation of interleukin-1 beta production
cellular response to amyloid-beta
ectopic germ cell programmed cell death
protein autoprocessing
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
actin filament organization
inflammatory response
regulation of apoptotic process
regulation of inflammatory response
innate immune response
Cellular Component
neuronal cell body
cytosol
cytoplasm
NLRP3 inflammasome complex
IPAF inflammasome complex
AIM2 inflammasome complex
endoplasmic reticulum
mitochondrion
plasma membrane
protein-containing complex
endoplasmic reticulum membrane
extracellular region
neuron projection
Molecular Function
cysteine-type endopeptidase activity
scaffold protein binding
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
CARD domain binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 373
Molecular Weight 42741.62
Theoretical pI 6.94
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P70343
UniProtKB/Swiss-Prot Entry Name CASP4_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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