| Identification |
|---|
| HMDB Protein ID
| HMDBP14433 |
| Secondary Accession Numbers
| None |
| Name
| 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 |
| Synonyms
|
- Fucosyltransferase 6
- Fucosyltransferase VI
- Galactoside 3-L-fucosyltransferase
- Fuc-TVI
- FucT-VI
|
| Gene Name
| FUT6 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or glycolipid-linked polylactosamines chain through an alpha-1,3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe(x)), Lewis X (Le(x)) and non sialylated VIM2 determinants. Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates to difucosylated sialyl Lewis x determinants. Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X. Does not have activity towards type 1 ((Galbeta1-3GlcNAc)) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates. |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| protein glycosylation |
| N-glycan fucosylation |
| Cellular Component |
| integral to membrane |
| Golgi apparatus |
| extracellular region |
| Golgi cisterna membrane |
| Molecular Function |
| 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 41847.3 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9GKU6 |
| UniProtKB/Swiss-Prot Entry Name
| FUT6_PONPY |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Koda Y, Tachida H, Pang H, Liu Y, Soejima M, Ghaderi AA, Takenaka O, Kimura H: Contrasting patterns of polymorphisms at the ABO-secretor gene (FUT2) and plasma alpha(1,3)fucosyltransferase gene (FUT6) in human populations. Genetics. 2001 Jun;158(2):747-56. doi: 10.1093/genetics/158.2.747. [PubMed:11404338 ]
|
