| Identification |
|---|
| HMDB Protein ID
| HMDBP14395 |
| Secondary Accession Numbers
| None |
| Name
| Hemagglutinin-neuraminidase |
| Synonyms
|
Not Available
|
| Gene Name
| HN |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| viral entry into host cell |
| virion attachment to host cell |
| Cellular Component |
| integral to membrane |
| viral envelope |
| host cell plasma membrane |
| virion membrane |
| Molecular Function |
| exo-alpha-(2->3)-sialidase activity |
| exo-alpha-(2->6)-sialidase activity |
| exo-alpha-(2->8)-sialidase activity |
| host cell surface receptor binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 63884.485 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P19762 |
| UniProtKB/Swiss-Prot Entry Name
| HN_MUMP1 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Kovamees J, Norrby E, Elango N: Complete nucleotide sequence of the hemagglutinin-neuraminidase (HN) mRNA of mumps virus and comparison of paramyxovirus HN proteins. Virus Res. 1989 Jan;12(1):87-96. doi: 10.1016/0168-1702(89)90056-7. [PubMed:2718627 ]
- Elliott GD, Yeo RP, Afzal MA, Simpson EJ, Curran JA, Rima BK: Strain-variable editing during transcription of the P gene of mumps virus may lead to the generation of non-structural proteins NS1 (V) and NS2. J Gen Virol. 1990 Jul;71 ( Pt 7):1555-60. doi: 10.1099/0022-1317-71-7-1555. [PubMed:2165137 ]
|
