| Identification |
|---|
| HMDB Protein ID
| HMDBP14360 |
| Secondary Accession Numbers
| None |
| Name
| Probable 9-O-acetyl-N-acetylneuraminic acid deacetylase |
| Synonyms
|
- Neu5,9Ac2 deacetylase
- Probable 9-O-acetyl-N-acetylneuraminate esterase
- Probable sialyl esterase NanS
|
| Gene Name
| NANS |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Probably catalyzes the hydrolysis of the 9-O-acetyl group of 9-O-acetyl-N-acetylneuraminate (Neu5,9Ac2). Is required for growth of E.coli on Neu5,9Ac2, an alternative sialic acid commonly found in mammalian host mucosal sites, in particular in the human intestine. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| carbohydrate metabolic process |
| N-acetylneuraminate metabolic process |
| carboxylic acid metabolic process |
| Cellular Component |
| periplasmic space |
| Molecular Function |
| sialate O-acetylesterase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 326 |
| Molecular Weight
| 36877.695 |
| Theoretical pI
| 6.514 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P39370 |
| UniProtKB/Swiss-Prot Entry Name
| NANS_ECOLI |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [PubMed:9278503 ]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [PubMed:16738553 ]
- Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. [PubMed:7610040 ]
- Condemine G, Berrier C, Plumbridge J, Ghazi A: Function and expression of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli. J Bacteriol. 2005 Mar;187(6):1959-65. doi: 10.1128/JB.187.6.1959-1965.2005. [PubMed:15743943 ]
- Steenbergen SM, Jirik JL, Vimr ER: YjhS (NanS) is required for Escherichia coli to grow on 9-O-acetylated N-acetylneuraminic acid. J Bacteriol. 2009 Nov;191(22):7134-9. doi: 10.1128/JB.01000-09. Epub 2009 Sep 11. [PubMed:19749043 ]
- Kalivoda KA, Steenbergen SM, Vimr ER: Control of the Escherichia coli sialoregulon by transcriptional repressor NanR. J Bacteriol. 2013 Oct;195(20):4689-701. doi: 10.1128/JB.00692-13. Epub 2013 Aug 9. [PubMed:23935044 ]
|
