| Identification |
|---|
| HMDB Protein ID
| HMDBP14355 |
| Secondary Accession Numbers
| None |
| Name
| Hemagglutinin-neuraminidase |
| Synonyms
|
Not Available
|
| Gene Name
| HN |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| viral entry into host cell |
| virion attachment to host cell |
| viral budding from plasma membrane |
| Cellular Component |
| integral to membrane |
| viral envelope |
| host cell plasma membrane |
| virion membrane |
| Molecular Function |
| identical protein binding |
| exo-alpha-(2->3)-sialidase activity |
| exo-alpha-(2->6)-sialidase activity |
| exo-alpha-(2->8)-sialidase activity |
| host cell surface receptor binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 62204.3 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P04850 |
| UniProtKB/Swiss-Prot Entry Name
| HN_PIV5 |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Baty DU, Southern JA, Randall RE: Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5. J Gen Virol. 1991 Dec;72 ( Pt 12):3103-7. doi: 10.1099/0022-1317-72-12-3103. [PubMed:1765772 ]
- Hiebert SW, Paterson RG, Lamb RA: Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: nucleotide sequence of the mRNA predicts an N-terminal membrane anchor. J Virol. 1985 Apr;54(1):1-6. doi: 10.1128/JVI.54.1.1-6.1985. [PubMed:3973974 ]
- Yuan P, Thompson TB, Wurzburg BA, Paterson RG, Lamb RA, Jardetzky TS: Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose. Structure. 2005 May;13(5):803-15. doi: 10.1016/j.str.2005.02.019. [PubMed:15893670 ]
|
