| Identification |
|---|
| HMDB Protein ID
| HMDBP14348 |
| Secondary Accession Numbers
| None |
| Name
| Hemagglutinin-neuraminidase |
| Synonyms
|
Not Available
|
| Gene Name
| HN |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| viral entry into host cell |
| virion attachment to host cell |
| Cellular Component |
| integral to membrane |
| viral envelope |
| host cell plasma membrane |
| virion membrane |
| Molecular Function |
| exo-alpha-(2->3)-sialidase activity |
| exo-alpha-(2->6)-sialidase activity |
| exo-alpha-(2->8)-sialidase activity |
| host cell surface receptor binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 64246.735 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P08492 |
| UniProtKB/Swiss-Prot Entry Name
| HN_PI3H4 |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Storey DG, Cote MJ, Dimock K, Kang CY: Nucleotide sequence of the coding and flanking regions of the human parainfluenza virus 3 hemagglutinin-neuraminidase gene: comparison with other paramyxoviruses. Intervirology. 1987;27(2):69-80. [PubMed:2822598 ]
- Elango N, Coligan JE, Jambou RC, Venkatesan S: Human parainfluenza type 3 virus hemagglutinin-neuraminidase glycoprotein: nucleotide sequence of mRNA and limited amino acid sequence of the purified protein. J Virol. 1986 Feb;57(2):481-9. doi: 10.1128/JVI.57.2.481-489.1986. [PubMed:3003381 ]
- Galinski MS, Mink MA, Pons MW: Molecular cloning and sequence analysis of the human parainfluenza 3 virus genes encoding the surface glycoproteins, F and HN. Virus Res. 1987 Sep;8(3):205-15. doi: 10.1016/0168-1702(87)90016-5. [PubMed:2825443 ]
- Huberman K, Peluso RW, Moscona A: Hemagglutinin-neuraminidase of human parainfluenza 3: role of the neuraminidase in the viral life cycle. Virology. 1995 Dec 1;214(1):294-300. doi: 10.1006/viro.1995.9925. [PubMed:8525632 ]
|
