| Identification |
|---|
| HMDB Protein ID
| HMDBP14339 |
| Secondary Accession Numbers
| None |
| Name
| Cytidine monophosphate-N-acetylneuraminic acid hydroxylase |
| Synonyms
|
- CMP-N-acetylneuraminic acid hydroxylase
- CMP-N-acetylneuraminate monooxygenase
- CMP-Neu5Ac hydroxylase
- CMP-NeuAc hydroxylase
|
| Gene Name
| CMAH |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. |
| Pathways
|
- N-acetylneuraminate metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| N-acetylneuraminate metabolic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| metal ion binding |
| 2 iron, 2 sulfur cluster binding |
| CMP-N-acetylneuraminate monooxygenase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 68017.62 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q8MJC6 |
| UniProtKB/Swiss-Prot Entry Name
| CMAH_PONPY |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Chou HH, Hayakawa T, Diaz S, Krings M, Indriati E, Leakey M, Paabo S, Satta Y, Takahata N, Varki A: Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11736-41. doi: 10.1073/pnas.182257399. Epub 2002 Aug 21. [PubMed:12192086 ]
- Stauffer RL, Walker A, Ryder OA, Lyons-Weiler M, Hedges SB: Human and ape molecular clocks and constraints on paleontological hypotheses. J Hered. 2001 Nov-Dec;92(6):469-74. doi: 10.1093/jhered/92.6.469. [PubMed:11948213 ]
|
