| Identification |
|---|
| HMDB Protein ID
| HMDBP14332 |
| Secondary Accession Numbers
| None |
| Name
| Cytidine monophosphate-N-acetylneuraminic acid hydroxylase |
| Synonyms
|
- CMP-N-acetylneuraminic acid hydroxylase
- CMP-N-acetylneuraminate monooxygenase
- CMP-Neu5Ac hydroxylase
- CMP-NeuAc hydroxylase
|
| Gene Name
| CMAH |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. |
| Pathways
|
- Amino sugar and nucleotide sugar metabolism
- N-acetylneuraminate metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| N-acetylneuraminate metabolic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| metal ion binding |
| 2 iron, 2 sulfur cluster binding |
| CMP-N-acetylneuraminate monooxygenase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 590 |
| Molecular Weight
| 68447.135 |
| Theoretical pI
| 6.67 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O97598 |
| UniProtKB/Swiss-Prot Entry Name
| CMAH_PANTR |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Chou HH, Takematsu H, Diaz S, Iber J, Nickerson E, Wright KL, Muchmore EA, Nelson DL, Warren ST, Varki A: A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11751-6. doi: 10.1073/pnas.95.20.11751. [PubMed:9751737 ]
|
