| Identification |
|---|
| HMDB Protein ID
| HMDBP14329 |
| Secondary Accession Numbers
| None |
| Name
| Hemagglutinin-neuraminidase |
| Synonyms
|
- HN protein
|
| Gene Name
| HN |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| viral entry into host cell |
| regulation of immune response |
| virion attachment to host cell |
| Cellular Component |
| integral to membrane |
| viral envelope |
| host cell plasma membrane |
| virion membrane |
| Molecular Function |
| exo-alpha-(2->3)-sialidase activity |
| exo-alpha-(2->6)-sialidase activity |
| exo-alpha-(2->8)-sialidase activity |
| host cell surface receptor binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 63409.37 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P04853 |
| UniProtKB/Swiss-Prot Entry Name
| HN_SENDZ |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Miura N, Nakatani Y, Ishiura M, Uchida T, Okada Y: Molecular cloning of a full-length cDNA encoding the hemagglutinin-neuraminidase glycoprotein of Sendai virus. FEBS Lett. 1985 Aug 19;188(1):112-6. doi: 10.1016/0014-5793(85)80885-1. [PubMed:2991016 ]
- Shioda T, Iwasaki K, Shibuta H: Determination of the complete nucleotide sequence of the Sendai virus genome RNA and the predicted amino acid sequences of the F, HN and L proteins. Nucleic Acids Res. 1986 Feb 25;14(4):1545-63. doi: 10.1093/nar/14.4.1545. [PubMed:3005975 ]
- Middleton Y, Tashiro M, Thai T, Oh J, Seymour J, Pritzer E, Klenk HD, Rott R, Seto JT: Nucleotide sequence analyses of the genes encoding the HN, M, NP, P, and L proteins of two host range mutants of Sendai virus. Virology. 1990 Jun;176(2):656-7. doi: 10.1016/0042-6822(90)90040-x. [PubMed:2161155 ]
- Tashiro M, James I, Karri S, Wahn K, Tobita K, Klenk HD, Rott R, Seto JT: Pneumotropic revertants derived from a pantropic mutant, F1-R, of Sendai virus. Virology. 1991 Sep;184(1):227-34. doi: 10.1016/0042-6822(91)90839-4. [PubMed:1651590 ]
- Markwell MA, Paulson JC: Sendai virus utilizes specific sialyloligosaccharides as host cell receptor determinants. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5693-7. doi: 10.1073/pnas.77.10.5693. [PubMed:6255459 ]
- Bousse T, Takimoto T, Gorman WL, Takahashi T, Portner A: Regions on the hemagglutinin-neuraminidase proteins of human parainfluenza virus type-1 and Sendai virus important for membrane fusion. Virology. 1994 Nov 1;204(2):506-14. doi: 10.1006/viro.1994.1564. [PubMed:7941317 ]
- Tanabayashi K, Compans RW: Functional interaction of paramyxovirus glycoproteins: identification of a domain in Sendai virus HN which promotes cell fusion. J Virol. 1996 Sep;70(9):6112-8. doi: 10.1128/JVI.70.9.6112-6118.1996. [PubMed:8709235 ]
- Takimoto T, Bousse T, Coronel EC, Scroggs RA, Portner A: Cytoplasmic domain of Sendai virus HN protein contains a specific sequence required for its incorporation into virions. J Virol. 1998 Dec;72(12):9747-54. doi: 10.1128/JVI.72.12.9747-9754.1998. [PubMed:9811709 ]
- Ali A, Nayak DP: Assembly of Sendai virus: M protein interacts with F and HN proteins and with the cytoplasmic tail and transmembrane domain of F protein. Virology. 2000 Oct 25;276(2):289-303. doi: 10.1006/viro.2000.0556. [PubMed:11040121 ]
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