| Identification |
|---|
| HMDB Protein ID
| HMDBP14214 |
| Secondary Accession Numbers
| None |
| Name
| Polysialic acid O-acetyltransferase |
| Synonyms
|
- Capsule O-acetyl transferase
|
| Gene Name
| NEUO |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the O-acetylation of capsular polymeric sialic acid. Shows high substrate specificity toward polymers of sialic acid that contains a large number of residues. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Molecular Function |
| polysialic-acid O-acetyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 307 |
| Molecular Weight
| 34518.02 |
| Theoretical pI
| 9.858 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A1ADJ6 |
| UniProtKB/Swiss-Prot Entry Name
| NEUO_ECOK1 |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Johnson TJ, Kariyawasam S, Wannemuehler Y, Mangiamele P, Johnson SJ, Doetkott C, Skyberg JA, Lynne AM, Johnson JR, Nolan LK: The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes. J Bacteriol. 2007 Apr;189(8):3228-36. doi: 10.1128/JB.01726-06. Epub 2007 Feb 9. [PubMed:17293413 ]
- Deszo EL, Steenbergen SM, Freedberg DI, Vimr ER: Escherichia coli K1 polysialic acid O-acetyltransferase gene, neuO, and the mechanism of capsule form variation involving a mobile contingency locus. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5564-9. doi: 10.1073/pnas.0407428102. Epub 2005 Apr 4. [PubMed:15809431 ]
- Bergfeld AK, Claus H, Vogel U, Muhlenhoff M: Biochemical characterization of the polysialic acid-specific O-acetyltransferase NeuO of Escherichia coli K1. J Biol Chem. 2007 Jul 27;282(30):22217-27. doi: 10.1074/jbc.M703044200. Epub 2007 May 22. [PubMed:17519228 ]
- Schulz EC, Bergfeld AK, Ficner R, Muhlenhoff M: Crystal structure analysis of the polysialic acid specific O-acetyltransferase NeuO. PLoS One. 2011 Mar 1;6(3):e17403. doi: 10.1371/journal.pone.0017403. [PubMed:21390252 ]
|
