| Identification |
|---|
| HMDB Protein ID
| HMDBP14200 |
| Secondary Accession Numbers
| None |
| Name
| N-acetylneuraminate lyase |
| Synonyms
|
- NAL
- Neu5Ac lyase
- N-acetylneuraminate pyruvate-lyase
- N-acetylneuraminic acid aldolase
- Sialate lyase
- Sialic acid aldolase
- Sialic acid lyase
|
| Gene Name
| NANA |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. |
| Pathways
|
- Amino sugar and nucleotide sugar metabolism
- N-acetylneuraminate degradation
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| carbohydrate metabolic process |
| N-acetylneuraminate catabolic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| N-acetylneuraminate lyase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 297 |
| Molecular Weight
| 32482.05 |
| Theoretical pI
| 5.854 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q5PLE9 |
| UniProtKB/Swiss-Prot Entry Name
| NANA_SALPA |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - McClelland M, Sanderson KE, Clifton SW, Latreille P, Porwollik S, Sabo A, Meyer R, Bieri T, Ozersky P, McLellan M, Harkins CR, Wang C, Nguyen C, Berghoff A, Elliott G, Kohlberg S, Strong C, Du F, Carter J, Kremizki C, Layman D, Leonard S, Sun H, Fulton L, Nash W, Miner T, Minx P, Delehaunty K, Fronick C, Magrini V, Nhan M, Warren W, Florea L, Spieth J, Wilson RK: Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid. Nat Genet. 2004 Dec;36(12):1268-74. doi: 10.1038/ng1470. Epub 2004 Nov 7. [PubMed:15531882 ]
|
