Hmdb loader
Identification
HMDB Protein ID HMDBP14198
Secondary Accession Numbers None
Name DNA polymerase kappa
Synonyms
  1. DINB protein
  2. DINP
Gene Name POLK
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:12432099). Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity).
Pathways
  • Basal cell carcinoma
  • Breast cancer
  • Chronic myeloid leukemia
  • Colorectal cancer
  • Endometrial cancer
  • Epstein-Barr virus infection
  • Fanconi anemia pathway
  • Gastric cancer
  • Glioma
  • Hepatocellular carcinoma
  • Melanoma
  • Non-small cell lung cancer
  • Pancreatic cancer
  • Small cell lung cancer
  • Thyroid cancer
  • Transcriptional misregulation in cancer
Reactions Not Available
GO Classification
Biological Process
DNA repair
DNA replication
response to DNA damage stimulus
nucleotide-excision repair, DNA gap filling
cellular response to UV
error-prone translesion synthesis
Cellular Component
nucleus
nucleoplasm
nuclear body
site of DNA damage
Molecular Function
metal ion binding
DNA-directed DNA polymerase activity
damaged DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 852
Molecular Weight 96001.985
Theoretical pI 6.703
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9QUG2
UniProtKB/Swiss-Prot Entry Name POLK_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Ogi T, Kato T Jr, Kato T, Ohmori H: Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB. Genes Cells. 1999 Nov;4(11):607-18. [PubMed:10620008 ]
  3. Gerlach VL, Aravind L, Gotway G, Schultz RA, Koonin EV, Friedberg EC: Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11922-7. [PubMed:10518552 ]
  4. Guo C, Fischhaber PL, Luk-Paszyc MJ, Masuda Y, Zhou J, Kamiya K, Kisker C, Friedberg EC: Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. EMBO J. 2003 Dec 15;22(24):6621-30. doi: 10.1093/emboj/cdg626. [PubMed:14657033 ]
  5. Ogi T, Shinkai Y, Tanaka K, Ohmori H: Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15548-53. doi: 10.1073/pnas.222377899. Epub 2002 Nov 13. [PubMed:12432099 ]