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Showing Protein Dimethylaniline monooxygenase [N-oxide-forming] 3 (HMDBP14193)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14193
Secondary Accession Numbers None
Name Dimethylaniline monooxygenase [N-oxide-forming] 3
Synonyms
  1. Dimethylaniline oxidase 3
  2. Hepatic flavin-containing monooxygenase 3
  3. Trimethylamine monooxygenase
  4. FMO 3
Gene Name FMO3
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
Pathways
  • Drug metabolism - cytochrome P450
Reactions Not Available
GO Classification
Biological Process
drug metabolic process
Cellular Component
integral to membrane
endoplasmic reticulum membrane
intracellular membrane-bounded organelle
Molecular Function
NADP binding
flavin adenine dinucleotide binding
amino acid binding
monooxygenase activity
N,N-dimethylaniline monooxygenase activity
trimethylamine monooxygenase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 531
Molecular Weight 59959.84
Theoretical pI 8.168
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 511-531;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9EQ76
UniProtKB/Swiss-Prot Entry Name FMO3_RAT
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Lattard V, Buronfosse T, Lachuer J, Longin-Sauvageon C, Moulin C, Benoit E: Cloning, sequencing, tissue distribution, and heterologous expression of rat flavin-containing monooxygenase 3. Arch Biochem Biophys. 2001 Jul 1;391(1):30-40. doi: 10.1006/abbi.2001.2317. [PubMed:11414682 ]
  3. Fargetton X, Galtier P, Delatour P: Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes. Vet Res Commun. 1986 Jul;10(4):317-24. doi: 10.1007/BF02213995. [PubMed:3739217 ]
  4. Moroni P, Buronfosse T, Longin-Sauvageon C, Delatour P, Benoit E: Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes. Drug Metab Dispos. 1995 Feb;23(2):160-5. [PubMed:7736906 ]
  5. Novick RM, Mitzey AM, Brownfield MS, Elfarra AA: Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes. J Pharmacol Exp Ther. 2009 Jun;329(3):1148-55. doi: 10.1124/jpet.109.152058. Epub 2009 Mar 23. [PubMed:19307449 ]