| Identification |
|---|
| HMDB Protein ID
| HMDBP14192 |
| Secondary Accession Numbers
| None |
| Name
| Dimethylaniline monooxygenase [N-oxide-forming] 3 |
| Synonyms
|
- Dimethylaniline oxidase 3
- Hepatic flavin-containing monooxygenase 3
- Trimethylamine monooxygenase
- FMO 3
|
| Gene Name
| FMO3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation. |
| Pathways
|
- Drug metabolism - cytochrome P450
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| drug metabolic process |
| Cellular Component |
| integral to membrane |
| endoplasmic reticulum membrane |
| intracellular membrane-bounded organelle |
| Molecular Function |
| NADP binding |
| flavin adenine dinucleotide binding |
| amino acid binding |
| monooxygenase activity |
| N,N-dimethylaniline monooxygenase activity |
| trimethylamine monooxygenase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 534 |
| Molecular Weight
| 60515.515 |
| Theoretical pI
| 8.373 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P97501 |
| UniProtKB/Swiss-Prot Entry Name
| FMO3_MOUSE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
- Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. Mol Cell Proteomics. 2009 May;8(5):904-12. doi: 10.1074/mcp.M800451-MCP200. Epub 2009 Jan 8. [PubMed:19131326 ]
- Falls JG, Cherrington NJ, Clements KM, Philpot RM, Levi PE, Rose RL, Hodgson E: Molecular cloning, sequencing, and expression in Escherichia coli of mouse flavin-containing monooxygenase 3 (FMO3): comparison with the human isoform. Arch Biochem Biophys. 1997 Nov 1;347(1):9-18. doi: 10.1006/abbi.1997.0322. [PubMed:9344459 ]
- Li Q, Korzan WJ, Ferrero DM, Chang RB, Roy DS, Buchi M, Lemon JK, Kaur AW, Stowers L, Fendt M, Liberles SD: Synchronous evolution of an odor biosynthesis pathway and behavioral response. Curr Biol. 2013 Jan 7;23(1):11-20. doi: 10.1016/j.cub.2012.10.047. Epub 2012 Nov 21. [PubMed:23177478 ]
|
