| Identification |
|---|
| HMDB Protein ID
| HMDBP14190 |
| Secondary Accession Numbers
| None |
| Name
| Dimethylaniline monooxygenase [N-oxide-forming] 3 |
| Synonyms
|
- Dimethylaniline oxidase 3
- Hepatic flavin-containing monooxygenase 3
- Trimethylamine monooxygenase
- FMO 3
|
| Gene Name
| FMO3 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation. |
| Pathways
|
- Drug metabolism - cytochrome P450
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| integral to membrane |
| endoplasmic reticulum membrane |
| Molecular Function |
| NADP binding |
| flavin adenine dinucleotide binding |
| monooxygenase activity |
| N,N-dimethylaniline monooxygenase activity |
| trimethylamine monooxygenase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 532 |
| Molecular Weight
| 60052.015 |
| Theoretical pI
| 7.939 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q7YS44 |
| UniProtKB/Swiss-Prot Entry Name
| FMO3_PANTR |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Cashman JR, Zhang J, Leushner J, Braun A: Population distribution of human flavin-containing monooxygenase form 3: gene polymorphisms. Drug Metab Dispos. 2001 Dec;29(12):1629-37. [PubMed:11717182 ]
|
