| Identification |
|---|
| HMDB Protein ID
| HMDBP14186 |
| Secondary Accession Numbers
| None |
| Name
| Selenoprotein N |
| Synonyms
|
- SePN
- SelN
|
| Gene Name
| SELENON |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage (By similarity). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:18713863). Plays an important role in muscle development and differentiation during early development. Required for development of the slow muscle fiber lineage (PubMed:18713863). Required for the correct organization and attachment of the myofibrils, as well as for the continuity and integrity of the connective tissue that forms the myoseptum (PubMed:17123513). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| calcium ion homeostasis |
| skeletal muscle fiber development |
| calcium-mediated signaling |
| muscle fiber development |
| muscle tissue development |
| regulation of ryanodine-sensitive calcium-release channel activity |
| Cellular Component |
| integral to membrane |
| endoplasmic reticulum membrane |
| Molecular Function |
| oxidoreductase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 557 |
| Molecular Weight
| 62623.19 |
| Theoretical pI
| 5.38 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q3Y4E2 |
| UniProtKB/Swiss-Prot Entry Name
| SELN_DANRE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Thisse C, Degrave A, Kryukov GV, Gladyshev VN, Obrecht-Pflumio S, Krol A, Thisse B, Lescure A: Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene Expr Patterns. 2003 Aug;3(4):525-32. doi: 10.1016/s1567-133x(03)00054-1. [PubMed:12915322 ]
- Deniziak M, Thisse C, Rederstorff M, Hindelang C, Thisse B, Lescure A: Loss of selenoprotein N function causes disruption of muscle architecture in the zebrafish embryo. Exp Cell Res. 2007 Jan 1;313(1):156-67. doi: 10.1016/j.yexcr.2006.10.005. Epub 2006 Oct 13. [PubMed:17123513 ]
- Jurynec MJ, Xia R, Mackrill JJ, Gunther D, Crawford T, Flanigan KM, Abramson JJ, Howard MT, Grunwald DJ: Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12485-90. doi: 10.1073/pnas.0806015105. Epub 2008 Aug 19. [PubMed:18713863 ]
|
