| Identification |
|---|
| HMDB Protein ID
| HMDBP14185 |
| Secondary Accession Numbers
| None |
| Name
| Protein S100-A1 |
| Synonyms
|
- S-100 protein alpha chain
- S-100 protein subunit alpha
- S100 calcium-binding protein A1
|
| Gene Name
| S100A1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:11909974, PubMed:16952982). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:17438143). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| negative regulation of transcription from RNA polymerase II promoter |
| positive regulation of voltage-gated calcium channel activity |
| positive regulation of sprouting angiogenesis |
| positive regulation of nitric-oxide synthase activity |
| regulation of heart contraction |
| Cellular Component |
| sarcoplasmic reticulum |
| cytoplasm |
| nucleus |
| Z disc |
| A band |
| M band |
| neuron projection |
| cytosol |
| nucleoplasm |
| I band |
| Golgi apparatus |
| Molecular Function |
| identical protein binding |
| calcium ion binding |
| protein homodimerization activity |
| calcium-dependent protein binding |
| ATPase binding |
| S100 protein binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 94 |
| Molecular Weight
| 10504.695 |
| Theoretical pI
| 4.489 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P56565 |
| UniProtKB/Swiss-Prot Entry Name
| S10A1_MOUSE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
- Ridinger K, Ilg EC, Niggli FK, Heizmann CW, Schafer BW: Clustered organization of S100 genes in human and mouse. Biochim Biophys Acta. 1998 Dec 10;1448(2):254-63. doi: 10.1016/s0167-4889(98)00137-2. [PubMed:9920416 ]
- Haimoto H, Kato K: S100a0 (alpha alpha) protein in cardiac muscle. Isolation from human cardiac muscle and ultrastructural localization. Eur J Biochem. 1988 Jan 15;171(1-2):409-15. doi: 10.1111/j.1432-1033.1988.tb13805.x. [PubMed:3276520 ]
- Du XJ, Cole TJ, Tenis N, Gao XM, Kontgen F, Kemp BE, Heierhorst J: Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice. Mol Cell Biol. 2002 Apr;22(8):2821-9. doi: 10.1128/MCB.22.8.2821-2829.2002. [PubMed:11909974 ]
- Most P, Seifert H, Gao E, Funakoshi H, Volkers M, Heierhorst J, Remppis A, Pleger ST, DeGeorge BR Jr, Eckhart AD, Feldman AM, Koch WJ: Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction. Circulation. 2006 Sep 19;114(12):1258-68. doi: 10.1161/CIRCULATIONAHA.106.622415. Epub 2006 Sep 4. [PubMed:16952982 ]
- Boerries M, Most P, Gledhill JR, Walker JE, Katus HA, Koch WJ, Aebi U, Schoenenberger CA: Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes. Mol Cell Biol. 2007 Jun;27(12):4365-73. doi: 10.1128/MCB.02045-06. Epub 2007 Apr 16. [PubMed:17438143 ]
|
