| Identification |
|---|
| HMDB Protein ID
| HMDBP14184 |
| Secondary Accession Numbers
| None |
| Name
| Css54 |
| Synonyms
|
- Non-disulfide-bridged peptide 3.2
- NDBP-3.2
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Amphipathic peptide that shows antibacterial activity against E.coli (MIC=12.5 ug/ml) and S.aureus (MIC=12.5 ug/ml). Increases efficacy of antibiotics (ethambutol, pyrazinamide, isoniazid, rifampicin) when tested against S.aureus, probably by facilitating their incorporation into the bacteria. Has hemolytic activity against human erythrocytes (25 uM provokes 83% of hemolysis). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| defense response to bacterium |
| hemolysis in other organism |
| Cellular Component |
| membrane |
| extracellular region |
| other organism cell membrane |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 2870.44 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0DL41 |
| UniProtKB/Swiss-Prot Entry Name
| NDB32_CENSU |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Garcia F, Villegas E, Espino-Solis GP, Rodriguez A, Paniagua-Solis JF, Sandoval-Lopez G, Possani LD, Corzo G: Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics. J Antibiot (Tokyo). 2013 Jan;66(1):3-10. doi: 10.1038/ja.2012.87. Epub 2012 Oct 24. [PubMed:23093034 ]
- Almaaytah A, Albalas Q: Scorpion venom peptides with no disulfide bridges: a review. Peptides. 2014 Jan;51:35-45. doi: 10.1016/j.peptides.2013.10.021. Epub 2013 Oct 31. [PubMed:24184590 ]
|
