| Identification |
|---|
| HMDB Protein ID
| HMDBP14181 |
| Secondary Accession Numbers
| None |
| Name
| Scaffold protein D13 |
| Synonyms
|
- 62 kDa protein
- Rifampicin resistance protein
|
| Gene Name
| (REFSEQ) VARIOLA VIRUS; HYPOTHETICAL PROTEIN |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| response to antibiotic |
| Cellular Component |
| membrane |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 551 |
| Molecular Weight
| 61891.37 |
| Theoretical pI
| 5.485 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0DOU9 |
| UniProtKB/Swiss-Prot Entry Name
| D13_VARV |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Massung RF, Esposito JJ, Liu LI, Qi J, Utterback TR, Knight JC, Aubin L, Yuran TE, Parsons JM, Loparev VN, et al.: Potential virulence determinants in terminal regions of variola smallpox virus genome. Nature. 1993 Dec 23-30;366(6457):748-51. [PubMed:8264798 ]
|
