| Identification |
|---|
| HMDB Protein ID
| HMDBP14169 |
| Secondary Accession Numbers
| None |
| Name
| Ribose-phosphate pyrophosphokinase |
| Synonyms
|
- RPPK
- 5-phospho-D-ribosyl alpha-1-diphosphate
- Phosphoribosyl diphosphate synthase
- Phosphoribosyl pyrophosphate synthase
- P-Rib-PP synthase
- PRPP synthase
- PRPPase
|
| Gene Name
| PRS |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). |
| Pathways
|
- 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis
- Biosynthesis of amino acids
- Biosynthesis of secondary metabolites
- Carbon metabolism
- Microbial metabolism in diverse environments
- Pentose phosphate pathway
- Purine metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| nucleotide biosynthetic process |
| nucleoside metabolic process |
| 5-phosphoribose 1-diphosphate biosynthetic process |
| ribonucleoside monophosphate biosynthetic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| magnesium ion binding |
| ATP binding |
| kinase activity |
| ribose phosphate diphosphokinase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 298 |
| Molecular Weight
| 32402.515 |
| Theoretical pI
| 4.783 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| A5UNK4 |
| UniProtKB/Swiss-Prot Entry Name
| KPRS_METS3 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Samuel BS, Hansen EE, Manchester JK, Coutinho PM, Henrissat B, Fulton R, Latreille P, Kim K, Wilson RK, Gordon JI: Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10643-8. doi: 10.1073/pnas.0704189104. Epub 2007 Jun 11. [PubMed:17563350 ]
|
