| Identification |
|---|
| HMDB Protein ID
| HMDBP14152 |
| Secondary Accession Numbers
| None |
| Name
| Zinc metalloproteinase/disintegrin |
| Synonyms
|
Not Available
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| impairs hemostasis in the envenomed animal.inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors alpha-IIb/beta-3 (ITGA2B/ITGB3). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| extracellular region |
| Molecular Function |
| metal ion binding |
| metalloendopeptidase activity |
| toxin activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 54005.575 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P30403 |
| UniProtKB/Swiss-Prot Entry Name
| VM2RH_CALRH |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Au LC, Chou JS, Chang KJ, Teh GW, Lin SB: Nucleotide sequence of a full-length cDNA encoding a common precursor of platelet aggregation inhibitor and hemorrhagic protein from Calloselasma rhodostoma venom. Biochim Biophys Acta. 1993 May 28;1173(2):243-5. doi: 10.1016/0167-4781(93)90190-o. [PubMed:7916635 ]
- Au LC, Huang YB, Huang TF, Teh GW, Lin HH, Choo KB: A common precursor for a putative hemorrhagic protein and rhodostomin, a platelet aggregation inhibitor of the venom of Calloselasma rhodostoma: molecular cloning and sequence analysis. Biochem Biophys Res Commun. 1991 Dec 16;181(2):585-93. doi: 10.1016/0006-291x(91)91230-a. [PubMed:1755841 ]
- Chang HH, Hu ST, Huang TF, Chen SH, Lee YH, Lo SJ: Rhodostomin, an RGD-containing peptide expressed from a synthetic gene in Escherichia coli, facilitates the attachment of human hepatoma cells. Biochem Biophys Res Commun. 1993 Jan 15;190(1):242-9. doi: 10.1006/bbrc.1993.1037. [PubMed:7916592 ]
- Chung MC, Ponnudurai G, Kataoka M, Shimizu S, Tan NH: Structural studies of a major hemorrhagin (rhodostoxin) from the venom of Calloselasma rhodostoma (Malayan pit viper). Arch Biochem Biophys. 1996 Jan 15;325(2):199-208. doi: 10.1006/abbi.1996.0025. [PubMed:8561498 ]
- Gould RJ, Polokoff MA, Friedman PA, Huang TF, Holt JC, Cook JJ, Niewiarowski S: Disintegrins: a family of integrin inhibitory proteins from viper venoms. Proc Soc Exp Biol Med. 1990 Nov;195(2):168-71. doi: 10.3181/00379727-195-43129b. [PubMed:2236100 ]
- Dennis MS, Henzel WJ, Pitti RM, Lipari MT, Napier MA, Deisher TA, Bunting S, Lazarus RA: Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2471-5. doi: 10.1073/pnas.87.7.2471. [PubMed:2320569 ]
- Adler M, Lazarus RA, Dennis MS, Wagner G: Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist. Science. 1991 Jul 26;253(5018):445-8. doi: 10.1126/science.1862345. [PubMed:1862345 ]
- Adler M, Wagner G: Sequential 1H NMR assignments of kistrin, a potent platelet aggregation inhibitor and glycoprotein IIb-IIIa antagonist. Biochemistry. 1992 Feb 4;31(4):1031-9. doi: 10.1021/bi00119a011. [PubMed:1734953 ]
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