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Showing Protein Arf-GAP with dual PH domain-containing protein 2 (HMDBP14125)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14125
Secondary Accession Numbers None
Name Arf-GAP with dual PH domain-containing protein 2
Synonyms
  1. Centaurin-alpha-2
  2. Cnt-a2
Gene Name ADAP2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
heart development
positive regulation of GTPase activity
inositol lipid-mediated signaling
Cellular Component
cytoplasm
plasma membrane
intracellular membrane-bounded organelle
mitochondrial envelope
Molecular Function
metal ion binding
GTPase activator activity
phosphatidylinositol-3,4,5-trisphosphate binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3,4-bisphosphate binding
protein-macromolecule adaptor activity
inositol 1,3,4,5 tetrakisphosphate binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 381
Molecular Weight 44348.46
Theoretical pI 9.367
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9NPF8
UniProtKB/Swiss-Prot Entry Name ADAP2_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Whitley P, Gibbard AM, Koumanov F, Oldfield S, Kilgour EE, Prestwich GD, Holman GD: Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle. Eur J Cell Biol. 2002 Apr;81(4):222-30. doi: 10.1078/0171-9335-00242. [PubMed:12018390 ]
  3. Jenne DE, Tinschert S, Stegmann E, Reimann H, Nurnberg P, Horn D, Naumann I, Buske A, Thiel G: A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions. Genomics. 2000 May 15;66(1):93-7. doi: 10.1006/geno.2000.6179. [PubMed:10843809 ]
  4. Hanck T, Stricker R, Sedehizade F, Reiser G: Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins. J Neurochem. 2004 Jan;88(2):326-36. doi: 10.1046/j.1471-4159.2003.02143.x. [PubMed:14690521 ]