Hmdb loader

Showing Protein Peptidyl-prolyl cis-trans isomerase FKBP35 (HMDBP14095)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP14095
Secondary Accession Numbers None
Name Peptidyl-prolyl cis-trans isomerase FKBP35
Synonyms
  1. PfFKBP35
Gene Name FKBP35
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Has peptidylprolyl isomerase (PPIase) and co-chaperone activities (PubMed:15664653, PubMed:15850699). Assists protein folding by catalyzing the peptidyl conversion of cis and trans rotamers of the prolyl amide bond of protein substrates (PubMed:15664653, PubMed:15850699, PubMed:23974147). Inhibits calcineurin phosphatase activity in vitro (PubMed:15850699, PubMed:17289400, PubMed:23974147). Plays an essential role in merozoite egress from host erythrocytes (PubMed:15664653, PubMed:23974147).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
protein folding
protein peptidyl-prolyl isomerization
chaperone-mediated protein folding
negative regulation of phosphoprotein phosphatase activity
Cellular Component
cytoplasm
nucleus
Molecular Function
protein dimerization activity
peptidyl-prolyl cis-trans isomerase activity
FK506 binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 304
Molecular Weight 34826.265
Theoretical pI 5.467
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8I4V8
UniProtKB/Swiss-Prot Entry Name FKB35_PLAF7
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. doi: 10.1038/nature01097. [PubMed:12368864 ]
  2. Monaghan P, Bell A: A Plasmodium falciparum FK506-binding protein (FKBP) with peptidyl-prolyl cis-trans isomerase and chaperone activities. Mol Biochem Parasitol. 2005 Feb;139(2):185-95. doi: 10.1016/j.molbiopara.2004.10.007. [PubMed:15664653 ]
  3. Kumar R, Adams B, Musiyenko A, Shulyayeva O, Barik S: The FK506-binding protein of the malaria parasite, Plasmodium falciparum, is a FK506-sensitive chaperone with FK506-independent calcineurin-inhibitory activity. Mol Biochem Parasitol. 2005 Jun;141(2):163-73. doi: 10.1016/j.molbiopara.2005.02.007. Epub 2005 Mar 19. [PubMed:15850699 ]
  4. Yoon HR, Kang CB, Chia J, Tang K, Yoon HS: Expression, purification, and molecular characterization of Plasmodium falciparum FK506-binding protein 35 (PfFKBP35). Protein Expr Purif. 2007 May;53(1):179-85. doi: 10.1016/j.pep.2006.12.019. Epub 2006 Dec 30. [PubMed:17289400 ]
  5. Kotaka M, Ye H, Alag R, Hu G, Bozdech Z, Preiser PR, Yoon HS, Lescar J: Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506. Biochemistry. 2008 Jun 3;47(22):5951-61. doi: 10.1021/bi800004u. Epub 2008 May 9. [PubMed:18465874 ]
  6. Kang CB, Ye H, Yoon HR, Yoon HS: Solution structure of FK506 binding domain (FKBD) of Plasmodium falciparum FK506 binding protein 35 (PfFKBP35). Proteins. 2008 Jan 1;70(1):300-2. doi: 10.1002/prot.21623. [PubMed:17876830 ]
  7. Alag R, Bharatham N, Dong A, Hills T, Harikishore A, Widjaja AA, Shochat SG, Hui R, Yoon HS: Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide. Protein Sci. 2009 Oct;18(10):2115-24. doi: 10.1002/pro.226. [PubMed:19691130 ]
  8. Harikishore A, Niang M, Rajan S, Preiser PR, Yoon HS: Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent. Sci Rep. 2013;3:2501. doi: 10.1038/srep02501. [PubMed:23974147 ]
  9. Bianchin A, Allemand F, Bell A, Chubb AJ, Guichou JF: Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution. Acta Crystallogr D Biol Crystallogr. 2015 Jun;71(Pt 6):1319-27. doi: 10.1107/S1399004715006239. Epub 2015 May 14. [PubMed:26057671 ]