Hmdb loader
Identification
HMDB Protein ID HMDBP14079
Secondary Accession Numbers None
Name Cytosolic non-specific dipeptidase
Synonyms
  1. CNDP dipeptidase 2
  2. Carnosine dipeptidase II
  3. Epididymis secretory protein Li 13
  4. Glutamate carboxypeptidase-like protein 1
  5. Peptidase A
Gene Name CNDP2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343).
Pathways
  • Arginine and proline metabolism
  • beta-Alanine metabolism
  • Histidine metabolism
Reactions Not Available
GO Classification
Biological Process
proteolysis
glutathione biosynthetic process
Cellular Component
cytosol
extracellular vesicular exosome
nucleoplasm
Molecular Function
metal ion binding
carboxypeptidase activity
peptidase activity
alanylglutamate dipeptidase activity
dipeptidase activity
metallodipeptidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 475
Molecular Weight 52878.08
Theoretical pI 5.969
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q96KP4
UniProtKB/Swiss-Prot Entry Name CNDP2_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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