| Identification |
|---|
| HMDB Protein ID
| HMDBP14059 |
| Secondary Accession Numbers
| None |
| Name
| Heme oxygenase (staphylobilin-producing) |
| Synonyms
|
- Heme-degrading monooxygenase
- Iron-regulated surface determinant
- Iron-responsive surface determinant
|
| Gene Name
| ISDG |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron. |
| Pathways
|
- Biosynthesis of secondary metabolites
- Porphyrin and chlorophyll metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| heme catabolic process |
| iron import into cell |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| iron ion binding |
| monooxygenase activity |
| heme binding |
| heme oxygenase (decyclizing) activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 104 |
| Molecular Weight
| 12024.525 |
| Theoretical pI
| 7.504 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q4L849 |
| UniProtKB/Swiss-Prot Entry Name
| HDOX_STAHJ |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K: Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species. J Bacteriol. 2005 Nov;187(21):7292-308. doi: 10.1128/JB.187.21.7292-7308.2005. [PubMed:16237012 ]
|
