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Showing Protein Zinc finger protein 16 (HMDBP14027)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP14027
Secondary Accession Numbers None
Name Zinc finger protein 16
Synonyms
  1. Zinc finger protein KOX9
Gene Name ZNF16
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively. Plays also a role as an inhibitor of cell apoptosis.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
cell division
positive regulation of cell cycle phase transition
cellular response to sodium dodecyl sulfate
positive regulation of megakaryocyte differentiation
positive regulation of kinase activity
positive regulation of erythrocyte differentiation
regulation of transcription from RNA polymerase II promoter
cell cycle
positive regulation of cell division
negative regulation of apoptotic process
positive regulation of cell proliferation
Cellular Component
nucleoplasm
nucleolus
nucleus
Molecular Function
metal ion binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 682
Molecular Weight 76471.135
Theoretical pI 7.973
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P17020
UniProtKB/Swiss-Prot Entry Name ZNF16_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [PubMed:19608861 ]
  4. Thiesen HJ: Multiple genes encoding zinc finger domains are expressed in human T cells. New Biol. 1990 Apr;2(4):363-74. [PubMed:2288909 ]
  5. Hendriks IA, Lyon D, Young C, Jensen LJ, Vertegaal AC, Nielsen ML: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat Struct Mol Biol. 2017 Mar;24(3):325-336. doi: 10.1038/nsmb.3366. Epub 2017 Jan 23. [PubMed:28112733 ]
  6. Peng H, Du ZW, Zhang JW: Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells. Leukemia. 2006 Jun;20(6):1109-16. doi: 10.1038/sj.leu.2404212. [PubMed:16628192 ]
  7. Deng MJ, Li XB, Peng H, Zhang JW: Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16). Mol Biotechnol. 2010 Feb;44(2):83-9. doi: 10.1007/s12033-009-9210-8. Epub 2009 Sep 15. [PubMed:19763908 ]
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