| Identification |
|---|
| HMDB Protein ID
| HMDBP14002 |
| Secondary Accession Numbers
| None |
| Name
| Cystathionine gamma-synthase |
| Synonyms
|
- CGS
- O-succinylhomoserine (thiol)-lyase
|
| Gene Name
| METB |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity). |
| Pathways
|
- Biosynthesis of amino acids
- Biosynthesis of secondary metabolites
- Cysteine and methionine metabolism
- Selenocompound metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| methionine biosynthetic process |
| transsulfuration |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| pyridoxal phosphate binding |
| cystathionine gamma-synthase activity |
| cystathionine gamma-synthase activity (acts on O-phosphohomoserine) |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 380 |
| Molecular Weight
| 41222.775 |
| Theoretical pI
| 6.468 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9ZMW7 |
| UniProtKB/Swiss-Prot Entry Name
| METB_HELPJ |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Alm RA, Ling LS, Moir DT, King BL, Brown ED, Doig PC, Smith DR, Noonan B, Guild BC, deJonge BL, Carmel G, Tummino PJ, Caruso A, Uria-Nickelsen M, Mills DM, Ives C, Gibson R, Merberg D, Mills SD, Jiang Q, Taylor DE, Vovis GF, Trust TJ: Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature. 1999 Jan 14;397(6715):176-80. doi: 10.1038/16495. [PubMed:9923682 ]
|
