| Identification |
|---|
| HMDB Protein ID
| HMDBP13994 |
| Secondary Accession Numbers
| None |
| Name
| Homoserine O-acetyltransferase |
| Synonyms
|
- HAT
- Homoserine transacetylase
- HTA
|
| Gene Name
| METAA |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. |
| Pathways
|
- Biosynthesis of amino acids
- Biosynthesis of secondary metabolites
- Cysteine and methionine metabolism
- L-methionine biosynthesis via de novo pathway
- Sulfur metabolism
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| homoserine O-acetyltransferase activity |
| homoserine O-succinyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 309 |
| Molecular Weight
| 35898.41 |
| Theoretical pI
| 5.333 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| M9SGV8 |
| UniProtKB/Swiss-Prot Entry Name
| METAA_METAX |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Bastard K, Perret A, Mariage A, Bessonnet T, Pinet-Turpault A, Petit JL, Darii E, Bazire P, Vergne-Vaxelaire C, Brewee C, Debard A, Pellouin V, Besnard-Gonnet M, Artiguenave F, Medigue C, Vallenet D, Danchin A, Zaparucha A, Weissenbach J, Salanoubat M, de Berardinis V: Parallel evolution of non-homologous isofunctional enzymes in methionine biosynthesis. Nat Chem Biol. 2017 Aug;13(8):858-866. doi: 10.1038/nchembio.2397. Epub 2017 Jun 5. [PubMed:28581482 ]
- Borrel G, Harris HM, Tottey W, Mihajlovski A, Parisot N, Peyretaillade E, Peyret P, Gribaldo S, O'Toole PW, Brugere JF: Genome sequence of "Candidatus Methanomethylophilus alvus" Mx1201, a methanogenic archaeon from the human gut belonging to a seventh order of methanogens. J Bacteriol. 2012 Dec;194(24):6944-5. doi: 10.1128/JB.01867-12. [PubMed:23209209 ]
|
