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Showing Protein Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (HMDBP13989)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13989
Secondary Accession Numbers None
Name Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
Synonyms
  1. NMN/NaMN adenylyltransferase 2
  2. Nicotinamide mononucleotide adenylyltransferase 2
  3. Nicotinate-nucleotide adenylyltransferase 2
  4. NMN adenylyltransferase 2
  5. NaMN adenylyltransferase 2
Gene Name NMNAT2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity).
Pathways
  • Biosynthesis of cofactors
  • NAD(+) biosynthesis
  • Nicotinate and nicotinamide metabolism
Reactions Not Available
GO Classification
Biological Process
NAD biosynthetic process
Cellular Component
axon
Golgi membrane
Golgi apparatus
cytoplasmic vesicle membrane
Molecular Function
ATP binding
nicotinamide-nucleotide adenylyltransferase activity
nicotinate-nucleotide adenylyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 304
Molecular Weight 34208.985
Theoretical pI 6.746
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q6PC93
UniProtKB/Swiss-Prot Entry Name NMNA2_DANRE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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