| Identification |
|---|
| HMDB Protein ID
| HMDBP13969 |
| Secondary Accession Numbers
| None |
| Name
| Beta-hexosaminidase Amuc_2136 |
| Synonyms
|
- Beta-N-acetylhexosaminidase Am2136
|
| Gene Name
| (GENBANK) GLYCOSIDE HYDROLASE |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Potentially capable of cleaving the specific glycoside linkages in the process of mucin degradation in human intestinal tract (Probable). Hydrolyzes synthetic substrate pNP-beta-GlcNAc with high activity and pNP-beta-GalNAc to a lot lesser extent. Does not hydrolyze pNP-alpha-GalNAc. |
| Pathways
|
- Amino sugar and nucleotide sugar metabolism
- Other glycan degradation
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| carbohydrate metabolic process |
| Molecular Function |
| beta-N-acetylhexosaminidase activity |
| N-acetyl-beta-D-galactosaminidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 756 |
| Molecular Weight
| 83778.875 |
| Theoretical pI
| 9.082 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| B2UPR7 |
| UniProtKB/Swiss-Prot Entry Name
| H2136_AKKM8 |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - van Passel MW, Kant R, Zoetendal EG, Plugge CM, Derrien M, Malfatti SA, Chain PS, Woyke T, Palva A, de Vos WM, Smidt H: The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes. PLoS One. 2011 Mar 3;6(3):e16876. doi: 10.1371/journal.pone.0016876. [PubMed:21390229 ]
- Chen X, Li M, Wang Y, Tang R, Zhang M: Biochemical characteristics and crystallographic evidence for substrate-assisted catalysis of a beta-N-acetylhexosaminidase in Akkermansia muciniphila. Biochem Biophys Res Commun. 2019 Sep 10;517(1):29-35. doi: 10.1016/j.bbrc.2019.06.150. Epub 2019 Jul 23. [PubMed:31345574 ]
|
