| Identification |
|---|
| HMDB Protein ID
| HMDBP13961 |
| Secondary Accession Numbers
| None |
| Name
| Main hemagglutinin component type C |
| Synonyms
|
- ANTP33
- HA 33 kDa subunit
- HA1
|
| Gene Name
| HA-33 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Agglutinates human erythrocytes (PubMed:2205574). The hemagglutinin (HA) component of the progenitor toxin protects the structural integrity of botulinum neurotoxin; may increase internalization of the neurotoxin into the bloodstream of the host (PubMed:9421908). The hemagglutinin (HA) component is involved in binding to the upper small intestine through interactions with glycolipids and glycoproteins containing sialic acid moieties (Probable). Binds galactose or oligosaccharides with galactose at their non-reducing end (PubMed:14663070). Binds eukaryotic host mucins; binding is inhibited by N-acetyl-beta-neuraminic acid, N-acetyl-D-galactosamine, galactose, and methyl N-acetyl-beta-neuraminic acid (PubMed:18178224). Binds N-acetyl-beta-neuraminic acid, N-acetyl-D-galactosamine and galactose (but not glucose) via 2 sites (PubMed:18178224, PubMed:21640703). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| pathogenesis |
| Cellular Component |
| extracellular region |
| Molecular Function |
| carbohydrate binding |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 286 |
| Molecular Weight
| 33752.445 |
| Theoretical pI
| 8.164 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0DPR0 |
| UniProtKB/Swiss-Prot Entry Name
| HA33C_CBCP |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Tsuzuki K, Kimura K, Fujii N, Yokosawa N, Indoh T, Murakami T, Oguma K: Cloning and complete nucleotide sequence of the gene for the main component of hemagglutinin produced by Clostridium botulinum type C. Infect Immun. 1990 Oct;58(10):3173-7. doi: 10.1128/iai.58.10.3173-3177.1990. [PubMed:2205574 ]
- Hauser D, Gibert M, Marvaud JC, Eklund MW, Popoff MR: Botulinal neurotoxin C1 complex genes, clostridial neurotoxin homology and genetic transfer in Clostridium botulinum. Toxicon. 1995 Apr;33(4):515-26. doi: 10.1016/0041-0101(94)00190-j. [PubMed:7570637 ]
- Fujinaga Y, Inoue K, Shimazaki S, Tomochika K, Tsuzuki K, Fujii N, Watanabe T, Ohyama T, Takeshi K, Inoue K, et al.: Molecular construction of Clostridium botulinum type C progenitor toxin and its gene organization. Biochem Biophys Res Commun. 1994 Dec 15;205(2):1291-8. doi: 10.1006/bbrc.1994.2805. [PubMed:7802661 ]
- Inoue K, Sobhany M, Transue TR, Oguma K, Pedersen LC, Negishi M: Structural analysis by X-ray crystallography and calorimetry of a haemagglutinin component (HA1) of the progenitor toxin from Clostridium botulinum. Microbiology (Reading). 2003 Dec;149(Pt 12):3361-3370. doi: 10.1099/mic.0.26586-0. [PubMed:14663070 ]
- Nakamura T, Tonozuka T, Ide A, Yuzawa T, Oguma K, Nishikawa A: Sugar-binding sites of the HA1 subcomponent of Clostridium botulinum type C progenitor toxin. J Mol Biol. 2008 Feb 22;376(3):854-67. doi: 10.1016/j.jmb.2007.12.031. Epub 2007 Dec 23. [PubMed:18178224 ]
- Nakamura T, Tonozuka T, Ito S, Takeda Y, Sato R, Matsuo I, Ito Y, Oguma K, Nishikawa A: Molecular diversity of the two sugar-binding sites of the beta-trefoil lectin HA33/C (HA1) from Clostridium botulinum type C neurotoxin. Arch Biochem Biophys. 2011 Aug 1;512(1):69-77. doi: 10.1016/j.abb.2011.05.012. Epub 2011 May 26. [PubMed:21640703 ]
|
