| Identification |
|---|
| HMDB Protein ID
| HMDBP13959 |
| Secondary Accession Numbers
| None |
| Name
| Arylsulfatase B |
| Synonyms
|
- ASB
- N-acetylgalactosamine-4-sulfatase
- G4S
|
| Gene Name
| ARSB |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). |
| Pathways
|
- Glycosaminoglycan degradation
- Lysosome
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| positive regulation of neuron projection development |
| colon epithelial cell migration |
| regulation of epithelial cell migration |
| Cellular Component |
| lysosome |
| cell surface |
| Molecular Function |
| metal ion binding |
| N-acetylgalactosamine-4-sulfatase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 535 |
| Molecular Weight
| 59752.53 |
| Theoretical pI
| 7.907 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P33727 |
| UniProtKB/Swiss-Prot Entry Name
| ARSB_FELCA |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Jackson CE, Yuhki N, Desnick RJ, Haskins ME, O'Brien SJ, Schuchman EH: Feline arylsulfatase B (ARSB): isolation and expression of the cDNA, comparison with human ARSB, and gene localization to feline chromosome A1. Genomics. 1992 Oct;14(2):403-11. doi: 10.1016/s0888-7543(05)80233-2. [PubMed:1427856 ]
- Haskins ME, Jezyk PF, Desnick RJ, Patterson DF: Animal model of human disease: Mucopolysaccharidosis VI Maroteaux-Lamy syndrome, Arylsulfatase B-deficient mucopolysaccharidosis in the Siamese cat. Am J Pathol. 1981 Nov;105(2):191-3. [PubMed:6794375 ]
|
