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Showing Protein Mycobactin import ATP-binding/permease protein IrtA (HMDBP13958)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13958
Secondary Accession Numbers None
Name Mycobactin import ATP-binding/permease protein IrtA
Synonyms
  1. Iron-regulated transporter A
Gene Name IRTA
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (PubMed:16385031, PubMed:19948799) (By similarity). Mycobactins are then reduced by the siderophore interaction domain to facilitate iron release in the bacterial cell (By similarity). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). Required for replication in human macrophages and in mouse lungs (PubMed:16385031).
Pathways
  • ABC transporters
Reactions Not Available
GO Classification
Biological Process
iron ion homeostasis
pathogenesis
cellular response to iron ion starvation
iron acquisition from host
response to host iron concentration
siderophore-dependent iron import into cell
Cellular Component
plasma membrane
integral to plasma membrane
Molecular Function
ATP binding
FAD binding
oxidoreductase activity
ATPase-coupled transmembrane transporter activity
siderophore transmembrane transporter activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 859
Molecular Weight 92964.92
Theoretical pI 7.421
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 293-313;335-355;409-429;433-453;520-540;549-569;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P9WQJ9
UniProtKB/Swiss-Prot Entry Name IRTA_MYCTU
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. doi: 10.1038/31159. [PubMed:9634230 ]
  2. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [PubMed:21969609 ]
  3. Rodriguez GM, Voskuil MI, Gold B, Schoolnik GK, Smith I: ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response. Infect Immun. 2002 Jul;70(7):3371-81. doi: 10.1128/IAI.70.7.3371-3381.2002. [PubMed:12065475 ]
  4. Rodriguez GM, Smith I: Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis. J Bacteriol. 2006 Jan;188(2):424-30. doi: 10.1128/JB.188.2.424-430.2006. [PubMed:16385031 ]
  5. Farhana A, Kumar S, Rathore SS, Ghosh PC, Ehtesham NZ, Tyagi AK, Hasnain SE: Mechanistic insights into a novel exporter-importer system of Mycobacterium tuberculosis unravel its role in trafficking of iron. PLoS One. 2008 May 7;3(5):e2087. doi: 10.1371/journal.pone.0002087. [PubMed:18461140 ]
  6. Ryndak MB, Wang S, Smith I, Rodriguez GM: The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain. J Bacteriol. 2010 Feb;192(3):861-9. doi: 10.1128/JB.00223-09. Epub 2009 Nov 30. [PubMed:19948799 ]