| Identification |
|---|
| HMDB Protein ID
| HMDBP13956 |
| Secondary Accession Numbers
| None |
| Name
| Cysteine proteinase inhibitor 1 |
| Synonyms
|
- KCPI1
- Phytocystatin
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Specific inhibitor of papain family cysteine proteinases. Inhibits papain, chymopapain, bromelain, ficin, human cathepsins B, H and L, actinidain and house dustmite endopeptidase 1, but does not inhibit human bleomycin hydrolase. Inhibits papain with an IC(50) of 2.47 nM. Does not inhibit cysteine proteinases belonging to other families including clostripain, streptopain and calpain. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| defense response |
| Cellular Component |
| extracellular region |
| Molecular Function |
| cysteine-type endopeptidase inhibitor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 12755.665 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q6TPK4 |
| UniProtKB/Swiss-Prot Entry Name
| CYT1_ACTDE |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Rassam M, Laing WA: Purification and characterization of phytocystatins from kiwifruit cortex and seeds. Phytochemistry. 2004 Jan;65(1):19-30. doi: 10.1016/j.phytochem.2003.09.019. [PubMed:14697268 ]
- Popovic MM, Milovanovic M, Burazer L, Vuckovic O, Hoffmann-Sommergruber K, Knulst AC, Lindner B, Petersen A, Jankov R, Gavrovic-Jankulovic M: Cysteine proteinase inhibitor Act d 4 is a functional allergen contributing to the clinical symptoms of kiwifruit allergy. Mol Nutr Food Res. 2010 Mar;54(3):373-80. doi: 10.1002/mnfr.200900035. [PubMed:19885843 ]
- Bublin M, Mari A, Ebner C, Knulst A, Scheiner O, Hoffmann-Sommergruber K, Breiteneder H, Radauer C: IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries. J Allergy Clin Immunol. 2004 Nov;114(5):1169-75. doi: 10.1016/j.jaci.2004.07.016. [PubMed:15536427 ]
|
