| Identification |
|---|
| HMDB Protein ID
| HMDBP13955 |
| Secondary Accession Numbers
| None |
| Name
| 2S albumin-like cysteine protease inhibitor |
| Synonyms
|
- AaCI-2S
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Cysteine protease inhibitor that likely functions in defense against insects by inhibiting cysteine proteases in the midgut of herbivore insects such as C.maculatus (PubMed:33266031). Selectively inhibits cathepsin L, as well as papain, ficin and bromelain with lower efficiency (PubMed:33266031). Shows antitumor activity, inhibiting the growth of prostate cancer cell lines PC3 and DU145, and the gastric cancer cell line Hs746T (PubMed:33266031). No activity against cathepsin B or serine proteases (trypsin, human plasma kallikrein and elastase) (PubMed:33266031). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 11012.345 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| C0HLT8 |
| UniProtKB/Swiss-Prot Entry Name
| CI2S_ARAAG |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Sallai RC, Salu BR, Silva-Lucca RA, Alves FL, Napoleao TH, Paiva PMG, da Silva Ferreira R, Sampaio MU, Vilela Oliva ML: Biotechnological Potential of Araucaria angustifolia Pine Nuts Extract and the Cysteine Protease Inhibitor AaCI-2S. Plants (Basel). 2020 Nov 30;9(12). pii: plants9121676. doi: 10.3390/plants9121676. [PubMed:33266031 ]
|
