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Showing Protein Nucleotide-binding oligomerization domain-containing protein 2 (HMDBP13949)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13949
Secondary Accession Numbers None
Name Nucleotide-binding oligomerization domain-containing protein 2
Synonyms
  1. Caspase recruitment domain-containing protein 15
  2. Inflammatory bowel disease protein 1
Gene Name NOD2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189).
Pathways
  • Inflammatory bowel disease
  • NOD-like receptor signaling pathway
  • TNF signaling pathway
  • Tuberculosis
Reactions Not Available
GO Classification
Biological Process
interleukin-1-mediated signaling pathway
positive regulation of interleukin-17 production
negative regulation of macrophage apoptotic process
nucleotide-binding oligomerization domain containing signaling pathway
positive regulation of innate immune response
cellular response to peptidoglycan
positive regulation of humoral immune response mediated by circulating immunoglobulin
cellular response to muramyl dipeptide
detection of biotic stimulus
negative regulation of interleukin-12 production
positive regulation of phosphatidylinositol 3-kinase activity
negative regulation of interferon-gamma production
detection of bacterium
detection of muramyl dipeptide
defense response
positive regulation of MAP kinase activity
defense response to Gram-positive bacterium
cellular response to organic cyclic compound
maintenance of gastrointestinal epithelium
positive regulation of interleukin-8 production
positive regulation of cytokine production involved in immune response
pattern recognition receptor signaling pathway
nucleotide-binding oligomerization domain containing 2 signaling pathway
activation of immune response
positive regulation of stress-activated MAPK cascade
positive regulation of monocyte chemotactic protein-1 production
positive regulation of dendritic cell cytokine production
positive regulation of B cell activation
innate immune response in mucosa
positive regulation of interleukin-10 production
positive regulation of NIK/NF-kappaB signaling
positive regulation of interleukin-6 production
positive regulation of interleukin-1 beta production
positive regulation of cytokine production involved in inflammatory response
negative regulation of toll-like receptor 2 signaling pathway
positive regulation of phagocytosis
positive regulation of tumor necrosis factor production
positive regulation of prostaglandin-E synthase activity
positive regulation of I-kappaB kinase/NF-kappaB cascade
negative regulation of T cell mediated immunity
negative regulation of NF-kappaB transcription factor activity
positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
cellular response to lipopolysaccharide
positive regulation of dendritic cell antigen processing and presentation
positive regulation of gamma-delta T cell activation
intracellular signal transduction
positive regulation of oxidoreductase activity
regulation of inflammatory response
positive regulation of prostaglandin-endoperoxide synthase activity
innate immune response
response to nutrient
positive regulation of protein K63-linked ubiquitination
positive regulation of xenophagy
regulation of neutrophil chemotaxis
response to muramyl dipeptide
positive regulation of JNK cascade
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
defense response to bacterium
negative regulation of interleukin-2 production
positive regulation of type 2 immune response
positive regulation of interleukin-12 production
negative regulation of tumor necrosis factor production
negative regulation of inflammatory response to antigenic stimulus
positive regulation of Notch signaling pathway
positive regulation of NF-kappaB transcription factor activity
JNK cascade
response to exogenous dsRNA
positive regulation of epithelial cell proliferation
activation of MAPK activity
negative regulation of interleukin-18 production
positive regulation of transcription from RNA polymerase II promoter
positive regulation of ERK1 and ERK2 cascade
Cellular Component
phagocytic vesicle
cytoplasm
cytosol
protein-containing complex
anchored to plasma membrane
mitochondrion
plasma membrane
cell surface
Golgi apparatus
vesicle
basolateral plasma membrane
cytoskeleton
Molecular Function
enzyme binding
ATP binding
protein kinase binding
actin binding
pattern recognition receptor activity
peptidoglycan binding
Hsp70 protein binding
Hsp90 protein binding
muramyl dipeptide binding
CARD domain binding
protein-containing complex binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 1040
Molecular Weight 115281.675
Theoretical pI 6.755
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9HC29
UniProtKB/Swiss-Prot Entry Name NOD2_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G: Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem. 2001 Feb 16;276(7):4812-8. doi: 10.1074/jbc.M008072200. Epub 2000 Nov 21. [PubMed:11087742 ]
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  15. Parkhouse R, Boyle JP, Mayle S, Sawmynaden K, Rittinger K, Monie TP: Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain. FEBS Lett. 2014 Aug 25;588(17):2830-6. doi: 10.1016/j.febslet.2014.06.035. Epub 2014 Jun 21. [PubMed:24960071 ]
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