| Identification |
|---|
| HMDB Protein ID
| HMDBP13914 |
| Secondary Accession Numbers
| None |
| Name
| Glycerophosphocholine cholinephosphodiesterase ENPP6 |
| Synonyms
|
- GPC-Cpde
- Choline-specific glycerophosphodiester phosphodiesterase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 6
- E-NPP 6
- NPP-6
|
| Gene Name
| ENPP6 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| lipid metabolic process |
| choline metabolic process |
| lipid catabolic process |
| Cellular Component |
| anchored to membrane |
| plasma membrane |
| Molecular Function |
| metal ion binding |
| glycerophosphocholine cholinephosphodiesterase activity |
| glycerophosphodiester phosphodiesterase activity |
| phosphoric diester hydrolase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 50355.595 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q58D68 |
| UniProtKB/Swiss-Prot Entry Name
| ENPP6_PIG |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Harhay GP, Sonstegard TS, Keele JW, Heaton MP, Clawson ML, Snelling WM, Wiedmann RT, Van Tassell CP, Smith TP: Characterization of 954 bovine full-CDS cDNA sequences. BMC Genomics. 2005 Nov 23;6:166. doi: 10.1186/1471-2164-6-166. [PubMed:16305752 ]
- Jorgensen FG, Hobolth A, Hornshoj H, Bendixen C, Fredholm M, Schierup MH: Comparative analysis of protein coding sequences from human, mouse and the domesticated pig. BMC Biol. 2005 Jan 28;3:2. doi: 10.1186/1741-7007-3-2. [PubMed:15679890 ]
- Uenishi H, Eguchi-Ogawa T, Shinkai H, Okumura N, Suzuki K, Toki D, Hamasima N, Awata T: PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Nucleic Acids Res. 2007 Jan;35(Database issue):D650-3. doi: 10.1093/nar/gkl954. Epub 2006 Dec 1. [PubMed:17145712 ]
|
